20–23 Sept 2023
Metropol Lake Resort, Ohrid
Europe/Skopje timezone

Engineering Multi-core Flower-like Magnetic Nanoparticles with High Intrinsic Loss Power

Not scheduled
20m
Metropol Lake Resort, Ohrid

Metropol Lake Resort, Ohrid

Poster presentation

Speaker

Miloš Ognjanović (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade)

Description

In the last decades, self-heating magnetic nanoparticles (MNPs) were engineered and investigated for magnetic hyperthermia (MH) and other applications such as catalysis and chemical synthesis. To be applied as nanoheaters for in vivo MH in cancer therapy, MNPs should have high heating efficiency expressed by Intrinsic Loss Power (ILP). One of the requirements for in vivo applications of MNPs is their non-toxicity. Hence, the most investigated MNPs for MH are based on iron oxides (magnetite and maghemite), which are non-toxic or slightly toxic. This work aimed to apply the polyol-mediated protocol to engineer mixed Zn1-xMnxFe2O4 and analyze their heating abilities. To obtain a series of Zn1-xMnxFe2O4 samples with a specific nominal composition, the initial components, salts of Zn, Mn and Fe, were mixed in the appropriate stoichiometric ratio. The deviation from the target stoichiometry and the formation of samples with polyvalent ions and possibly vacancies were determined after ICP analysis. By analyzing TEM micrographs, we found that the change in the chemical composition does not affect the morphology. Multicore flower-like nanostructures with a size in the range of 47-63 nm were obtained. They consist of many cores (crystallites or nanoparticles) with a size of ~10 nm. The samples show good colloidal stability, which is significant for their medical applications. Magnetization measurements in different DC fields showed that the samples are superparamagnetic at 300 K and that the saturation magnetization values are in the range of ~59-73 emu/g. The hyperthermic efficiency of the synthesized samples was tested in an external ac field of 252 kHz and a field strength of 15.9 kA/m. Significantly different values were obtained for the ILP parameter (in units nHm2/Kg): 5.77 (Zn0.098Mn0.447Fe2.455O4) ˃ 3.22 (Mn0.624Fe2.376O4) ˃ 2.04 (Zn0.182Mn0.344Fe2.474O4) ˃ 1.36 (Zn0.309Mn0.240Fe2.451O4) ˃ 1.01 (Zn0.394Mn0.138Fe2.468O4) ˃ 0.34 (Zn0.640Fe2.360O4). To explain the values of the ILP parameter, additional research is required, which includes the analysis of the influence of local defects and cation distribution on the magnetism of the investigated nanostructures. Also, significantly high ILP values indicate that some samples can be selected and further tested for in vitro/in vivo applications.

Primary authors

Miloš Ognjanović (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade) Dr Magdalena Radović (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade) Marija Mirković (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade) Dr Sanja Vranješ-Đurić (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade) Dr Biljana Dojčinović (University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia) Prof. Dalibor Stanković (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade) Dr Bratislav Antić (VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade)

Presentation materials