Speaker
Description
Over the past decade, polymer nanocomposites have significantly advanced electrochemical sensors for therapeutic drug monitoring and chemotherapy dose control. This study develops screen-printed polymer and polymer-composite electrochemical sensors evaluated across four surface modification strategies: a composite ink with a synthesized nanohybrid, an applied polymer layer, an electropolymerized polymer, and β-particle irradiation.
A nanohybrid of reduced graphene oxide decorated with gold nanoparticles was synthesized as the active ink component. Comprehensive physicochemical characterization was conducted using XRD, Raman, FTIR, SEM-EDS, DSC, and TGA/DTA. The modified electrodes, incorporating commercial carbon, nanomaterial, and noble metal inks, were tested for doxorubicin detection in phosphate buffer across 1.5–22.1 mol/L. Cyclic voltammetry and UV-Vis spectroscopy were employed alongside full analytical method validation. Compared to unmodified controls, the modified electrodes exhibited significantly enhanced electrochemical response, demonstrating higher sensitivity, faster reaction kinetics, and lower limits of detection and quantification. These results confirm the success of the modification methodologies for practical clinical applications.
Keywords: electrochemical sensor, polymer-modified electrodes, screen-printed electrodes, cytotoxic agents, nanocomposite.
| Conference Topics | Nanomaterials and Nanotechnology |
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