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Description
Noscapine is a pharmacologically relevant phthalide isoquinoline alkaloid which was historically used as an antitussive agent, but in recent years has attracted increasing interest in its potential anticancer activity. Owing to its structural similarity to other opium alkaloids and the complexity of matrices in which it may be encountered, its determination requires sensitive and selective analytical methodologies. In this study, the electrochemical behavior of noscapine was investigated using cyclic voltammetry with multi-walled carbon nanotube-modified screen-printed electrodes, with the aim of developing an electrochemical sensor based on molecularly imprinted polymers.
Voltammetric measurements were performed to characterize the electrochemical response of noscapine on the MWCNT-modified electrode surface. Electrochemical kinetics were evaluated using Tafel analysis, yielding a Tafel slope of 200 mV dec-1, suggesting relatively slow electron-transfer kinetics. A kinetic slope of 0.48 indicates that the electrode process is predominantly diffusion-controlled. The influence of solution pH on the electrochemical process was examined in the range of pH 3 – 11, with the optimal analytical response observed at pH 6.8. These findings provide fundamental insight into the electrochemical characteristics of noscapine at MWCNT-modified SPEs and establish the basis for further modification and optimization of the sensor. Further work will focus on enhancing selectivity and sensitivity through molecular imprinting.
| Conference Topics | Biomedical Applications of Materials |
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