Speaker
Description
Doxorubicin (DOX), a widely used anthracycline chemotherapeutic drug, poses environmental risks due to its persistence and toxicity, creating a need for rapid and sensitive detection techniques. In this context, electrochemical sensors (ECS) have emerged as efficient tools for DOX detection, offering high sensitivity, selectivity, and fast response. The performance of such sensors can be further enhanced by modifying the electrode surface to facilitate charge transfer and improve detection efficiency.
In this work, ZnO/GO composites with 0.01 and 0.05 wt% GO were synthesized via microwave processing of Zn(OH)2 precipitate and used as electrode modifiers for DOX detection. The physicochemical properties of the ZnO/GO composites were characterized using X-ray powder diffraction (XRD), Raman and Fourier-transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), UV–Vis diffuse reflectance spectroscopy (DRS), and photoluminescence (PL) spectroscopy. Cyclic voltammetry (CV) was used to study the electrochemical response of DOX on a ZnO/GO-modified glassy carbon electrode. CV measurements were carried out in 25 mL of phosphate buffer solution (0.1 M, pH 7.0) with successive additions of doxorubicin infusion solution (Ebewe Pharma, 50 mg DOX / 25 mL) in portions ranging from 10 to 350 μL. All experiments were performed within the potential range of –0.4 to 0.6 V at a scan rate of 50 mV·s-1. Electrochemical sensitivity of ZnO/GO composites toward DOX was correlated with their physicochemical characteristics.
Acknowledgement: The authors KA, AS, ISS, and SM acknowledge the financial support from the Science Fund of the Republic of Serbia, The Program PRISMA, #7377, Water pollutants detection by ZnO-modified electrochemical sensors: From computational modeling via electrochemical testing to real system application – WaPoDe.
